Long-term Treatment of Acromegaly and Gigantism with Octreotide (SMS 201-995)

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Treatment of acromegaly with long acting somatostatin analogue SMS 201-995.

Ten acromegalic patients were treated with the somatostatin analogue SMS 201-995 (SMS) for 3-38 weeks in various doses and by different administration routines (thrice daily or multiple sc injection). Plasma GH daily profiles, plasma IGF-I, urinary GH, serum TSH, IRI and fasting blood glucose (FBG) concentrations were measured before and during SMS treatment. Plasma GH rapidly decreased within ...

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This study was supported in part by a centre grant from the National Health and Medical Research Council of Australia and a grant from Sandoz Pharma, Basle, Switzerland. 1 Ho KY, Weissberger AJ, Marbach P, Lazarus L. Therapeutic efficacy of the somatostatin analog SMS 201-995 (octreotide) in acromegaly: effects of dose and frequency and long term safety. Ann Intern Med 1990;112:173-81. 2 Sassol...

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ژورنال

عنوان ژورنال: Folia Endocrinologica Japonica

سال: 1992

ISSN: 0029-0661

DOI: 10.1507/endocrine1927.68.2_89