Long-term Treatment of Acromegaly and Gigantism with Octreotide (SMS 201-995)

Treatment of acromegaly with long acting somatostatin analogue SMS 201-995.

Ten acromegalic patients were treated with the somatostatin analogue SMS 201-995 (SMS) for 3-38 weeks in various doses and by different administration routines (thrice daily or multiple sc injection). Plasma GH daily profiles, plasma IGF-I, urinary GH, serum TSH, IRI and fasting blood glucose (FBG) concentrations were measured before and during SMS treatment. Plasma GH rapidly decreased within ...

Somatostatin analogue SMS 201-995 long term therapy for vipoma.

The definitive treatment of a pancreatic tumour secreting vasoactive intestinal polypeptide is surgical removal of the tumour, but when curative resection is not possible symptomatic treatment of the endocrine hyperfunction is important. Streptozotocin, although effective for palliation, can involve unpleasant side effects. We report the long term use of subcutaneous somatostatin analogue SMS 2...

The Effect of Long Acting Somatostatin Analogue SMS 201-995 in Acromegaly

GH Secretory Dynamics and Responsiveness to SMS 201-995 Treatment in Acromegaly

Oral and dental disease in terminally ill cancer patients.

This study was supported in part by a centre grant from the National Health and Medical Research Council of Australia and a grant from Sandoz Pharma, Basle, Switzerland. 1 Ho KY, Weissberger AJ, Marbach P, Lazarus L. Therapeutic efficacy of the somatostatin analog SMS 201-995 (octreotide) in acromegaly: effects of dose and frequency and long term safety. Ann Intern Med 1990;112:173-81. 2 Sassol...